Chronic kidney disease (CKD) is characterized by irreversible pathological processes that
result in the development of end-stage renal disease (ESRD). Accumulating evidence has …

Congenital obstructive nephropathy accounts for the greatest fraction of chronic kidney
disease in children. Genetic and nongenetic factors responsible for the lesions are largely …

Epithelial cell fate and nephron loss in obstructive uropathy are not fully understood. We
produced transgenic mice in which epithelial cells in the nephrons and collecting ducts were …

Chronic kidney disease is characterized by the decline in renal excretory, homeostatic and
endocrine functions. In most instances, the primary event is glomerular injury. With ongoing …

Urinary tract obstruction is a frequent cause of renal impairment. The physiopathology of
obstructive nephropathy has long been viewed as a mere mechanical problem. However …

Myosin VI (Myo6) is an actin‐based molecular motor involved in clathrin‐mediated
endocytosis that is highly expressed in the renal proximal tubule brush border. We …

Connective tissue growth factor (CTGF) plays a key role in renal fibrosis. Urinary CTGF is
elevated in various renal diseases and may have biomarker potential. However, it is …

To investigate the role of endogenous inducible nitric oxide synthase (iNOS) in the response
of the developing kidney to unilateral ureteral obstruction (UUO), neonatal iNOS null mutant …

Pelvi-ureteric junction obstruction is an important cause of congenital renal and urinary tract
abnormality. It is the commonest cause of antenatally detected hydronephrosis. The …