Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular
understanding of their mechanism of action is still lacking. Here we summarize current …

Phagocytosis serves as one of the key processes involved in development, maintenance of
tissue homeostasis, as well as in eliminating pathogens from an organism. Under normal …

Defensins are cationic and disulfide-bonded host defense proteins of many animals that
target microbial cell membranes. Elucidating the three-dimensional structure, dynamics, and …

Thanatin, a 21-residue peptide, is an inducible insect peptide. In our previous study, we
have identified a novel thanatin analog of S-thanatin, which exhibited a broad antimicrobial …

S-thanatin, an analog of thanatin, was synthesized by substituting the 15th amino acid of
threonine with serine, which showed a broad antimicrobial activity against bacteria. We …

In every living cell, the lipid bilayer membrane is the ultimate boundary between the contents
of the cell and the rest of universe. A single breach in this critical barrier is lethal. For this …

Classical antibiotics work by inhibiting bacterial cell wall synthesis, protein synthesis, DNA
(deoxyribonucleic acid) replication, or by modifying metabolism. Bacteria can resist …

目的: 研究抗菌肽Thanatin 同系物(S-thanatin, Ts) 的作用机制以及靶位. 方法: 进行Ts
与脂多糖(LPS) 的结合作用实验, 用不同组分的磷脂制备出包裹了钙黄绿素的脂质体来模拟多肽 …

The inflammatory bowel diseases (IBD), Crohn‟ s disease (CD [MIM 266600]), Ulcerative
Colitis (UC [MIM 191390]), are common causes of chronic gastrointestinal morbidity …

We are exposed daily to a myriad of potential pathogens, mainly through dermal contact,
ingestion and inhalation. The innate immune system is of crucial importance in preventing …