Many types of human cancer are characterized by deregulation of the human epidermal
growth factor receptor (HER) family of tyrosine kinase receptors. In some cancers, genomic …

Indole compounds, obtained from cruciferous vegetables, have been investigated for their
putative anti-cancer properties. Studies with indole-3-carbinol (I3C) and its dimeric product …

By incorporating histone deacetylase (HDAC) inhibitory functionality into the
pharmacophore of the epidermal growth factor receptor (EGFR) and human epidermal …

Receptor tyrosine kinase inhibitors have recently become important therapeutics for a
variety of cancers. However, due to the heterogeneous and dynamic nature of tumors, the …

Quiescent and tumor cells share the ability to evade irreversible cell fates. Recent studies
have shown that the transcriptional regulator Hairy and Enhancer of Split 1 (HES1) protects …

Inhibitors of protein deacetylases have recently been established as a novel therapeutic
principle for several human diseases, including cancer. The original notion of the …

Epigenetics refers to a stable, mitotically perpetuated regulatory mechanism of gene
expression without an alteration of the coding sequence. Epigenetic mechanisms include …

Purpose We conducted a phase I/II clinical trial to determine the safety and feasibility of
combining vorinostat with 5-fluorouracil (5-FU) in patients with metastatic colorectal cancer …

Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional
therapies and do not respond to radioiodine and comprises metastatic or recurrent …

Histone Deacetylases (HDACs) enzymes are critical in regulating gene expression and
transcription. They also play a fundamental role in regulating cellular activities such as cell …