Members of the CD44 family of transmembrane glycoproteins, in particular CD44v6
isoforms, were shown to be metastatic determinants of rat pancreatic tumour cells back in …

Multiple myeloma is an incurable hematological malignancy of terminally differentiated
immunoglobulin-producing plasma cells. As a common presentation of the disease, the …

Mesenchymal stromal cells (MSC) have been suggested to provide a suitable cellular
environment for in vitro expansion of haematopoietic stem and progenitor cells (HPC) from …

Homing of chronic lymphocytic leukemia (CLL) cells to sites favoring growth, a critical step in
disease progression, is principally coordinated by the CXCL12/CXCR4 axis. A cohort of 62 …

Prostate cancer is the most common malignancy in men, and patients with metastatic
disease have poor outcome even with the most advanced therapeutic approaches. Most …

Umbilical cord blood (UCB) has been used successfully as a source of hematopoietic stem
cells (HSCs) for allogeneic transplantation in children and adults in the treatment of …

Specific cell–cell junctions between hematopoietic stem cells (HSC) and their niche have
been shown to regulate stem cell function. N-cadherin was suggested to play a central role …

Background. The chemokine stromal cell-derived factor-1 (SDF-1) is thought to be involved
in mediating tissue repair by promoting migration of bone marrow stem or progenitor cells to …

Poor prognosis of acute leukemia with current treatments is mainly due to the relapse of the
disease following chemotherapy. In the last decade, an emerging concept has proposed that …

Despite recent advances, treatment of leukemia is often not curative. New insights indicate
that this may be attributable to a small population of therapy-resistant malignant cells with …