BACKGROUND: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant,
is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G …

Background The lymphatic system plays critical roles in tissue fluid homoeostasis, immune
defence and metabolic maintenance. Lymphatic vessels transport lymph, proteins, immune …

The chemokine family consists of approximately 50 small (8–14 kDa), basic proteins that are
expressed and released by a wide range of normal and malignant cells. Based on their …

Proinflammatory CC chemokines are thought to drive recruitment of maternal leukocytes into
gestational tissues and regulate extravillous trophoblast migration. The atypical chemokine …

Chemokines induce cell migration through the activation of a distinct family of structurally
related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several …

In a recent effort to unravel the molecular basis of prostate cancer (PCa), Barbieri and
colleagues using whole-exome sequencing identified a novel recurrently mutated gene …

Thirteen years ago the first decoy receptor was identified (ie, IL-1 receptor type II). Lacking a
cytoplasmic domain, it binds IL-1b, without triggering signal transduction. Thus the receptor …

Background. Inflammatory cell recruitment during allograft rejection is driven by a group of
inflammatory cytokines termed chemokines. Chemokines are presented on the surface of …

Chemokines are a large subfamily of cytokines (50 in humans) that can be distinguished
from other cytokines due to several features. They share a common biological activity, which …

This chapter contains sections titled: D6, an Atypical Receptor for Pro‐Inflammatory CC
Chemokines CCX‐CKR, an Atypical Receptor for Homeostatic CC Chemokines CXCR7: A …