Airway remodelling refers to the structural changes that occur in both large and small
airways relevant to miscellaneous diseases including asthma. In asthma, airway structural …

Allergic diseases such as asthma result from inappropriate immunologic responses to
common environmental allergens in genetically susceptible individuals. Following allergen …

Background: Our understanding of the pathogenic role of IgE in atopic dermatitis is
incomplete. We asked whether blocking free IgE would alter the course of the disease …

Eosinophilia is an established marker of asthma-related inflammation. We assessed the
effect of omalizumab on peripheral blood eosinophil counts using a pooled analysis of data …

A biological marker (biomarker) is a physical sign or laboratory measurement that can serve
as an indicator of biological or pathophysiological processes or as a response to a …

BACKGROUND: It is documented that omalizumab treatment reduces the cell surface
expression of immunoglobulin E high-affinity receptor (FcɛRI) on several cell types. This has …

Background: Treating asthmatics with the humanized IgE-scavenging antibody, omalizumab
(rhuMAb-E25, Xolair®), reduces airways inflammation and asthma symptoms. Previously …

BACKGROUND: In human basophils from different subjects, maximum IgE-mediated
histamine release and the level of Syk protein expression correlate well. Recent studies …

Background: Omalizumab is a humanized monoclonal anti-IgE antibody, especially useful
for the treatment of severe persistent allergic asthma, inadequately controlled despite …

The terms asthma and chronic obstructive pulmonary disease have evolved from their
original very specific physiology‐based definition to describe additional disease entities …