Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …
play an important role in the control of gene expression. In mammals, epigenetic …
[HTML][HTML] Epigenetics and cancer
Epigenetic modifications are central to many human diseases, including cancer.
Traditionally, cancer has been viewed as a genetic disease, and it is now becoming …
Traditionally, cancer has been viewed as a genetic disease, and it is now becoming …
[PDF][PDF] An Oct4-centered protein interaction network in embryonic stem cells
DLC van den Berg, T Snoek, NP Mullin, A Yates… - Cell stem cell, 2010 - cell.com
Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …
cell identity. Whereas the genomic locations of several pluripotency transcription factors …
The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage
G Smeenk, WW Wiegant, H Vrolijk, AP Solari… - Journal of Cell …, 2010 - rupress.org
Cells respond to ionizing radiation (IR)–induced DNA double-strand breaks (DSBs) by
orchestrating events that coordinate cell cycle progression and DNA repair. How cells signal …
orchestrating events that coordinate cell cycle progression and DNA repair. How cells signal …
[HTML][HTML] Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists
D Mossman, KT Kim, RJ Scott - BMC cancer, 2010 - Springer
Background DNA methylation and histone acetylation are epigenetic modifications that act
as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a …
as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a …
Promoter methylation in prostate cancer and its application for the early detection of prostate cancer using serum and urine samples
H Ahmed - Biomarkers in cancer, 2010 - journals.sagepub.com
Prostate cancer is the second most common cancer and the second leading cause of cancer
death in men. However, prostate cancer can be effectively treated and cured, if it is …
death in men. However, prostate cancer can be effectively treated and cured, if it is …
[HTML][HTML] Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6
AL Chokas, CM Trivedi, MM Lu, PW Tucker, S Li… - Journal of biological …, 2010 - ASBMB
To determine the underlying mechanism of Foxp1/2/4-mediated transcriptional repression, a
yeast two-hybrid screen was performed that identified p66β, a transcriptional repressor and …
yeast two-hybrid screen was performed that identified p66β, a transcriptional repressor and …
Possible involvement of DNA methylation in NKCC1 gene expression during postnatal development and in response to ischemia
J. Neurochem.(2010) 114, 520–529. Abstract In CNS, GABAA receptor‐mediated responses
switch from depolarization to hyperpolarization during postnatal development. This switch is …
switch from depolarization to hyperpolarization during postnatal development. This switch is …
[HTML][HTML] Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions
MM Spain, JA Caruso, A Swaminathan… - Journal of biological …, 2010 - ASBMB
The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC)
complexes. SIN3 and its associated HDAC have been shown to have critical roles in both …
complexes. SIN3 and its associated HDAC have been shown to have critical roles in both …
Mi-2/NuRD complex making inroads into DNA-damage response pathway
DQ Li, R Kumar - Cell Cycle, 2010 - Taylor & Francis
In eukaryotic cells, packaging of DNA into highly condensed chromatin presents a significant
obstacle to DNA-based processes. Cells use two major strategies including histone …
obstacle to DNA-based processes. Cells use two major strategies including histone …