Multiple sclerosis: risk factors, prodromes, and potential causal pathways
Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …
MS is not yet known, although epidemiological data indicate that both genetic and …
HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis
D Guimaraães Brum, AA Barreira… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple
sclerosis (MS), which has a strong predilection for Caucasian populations, whereas NMO is …
sclerosis (MS), which has a strong predilection for Caucasian populations, whereas NMO is …
MGAT5 alters the severity of multiple sclerosis
B Brynedal, J Wojcik, F Esposito, V Debailleul… - Journal of …, 2010 - Elsevier
Multiple Sclerosis (MS) is a genetically complex immune mediated, demyelinating disease
of the central nervous system. To date no genetic variants have been unambiguously linked …
of the central nervous system. To date no genetic variants have been unambiguously linked …
Pediatric multiple sclerosis
S Venkateswaran, B Banwell - The neurologist, 2010 - journals.lww.com
Background: Pediatric multiple sclerosis (MS), once considered a rare childhood illness, has
been increasingly identified as an important childhood acquired neurologic disease …
been increasingly identified as an important childhood acquired neurologic disease …
[HTML][HTML] Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients
Recent association studies in multiple sclerosis (MS) have identified and replicated several
single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R …
single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R …
Anticipation of age at onset in familial multiple sclerosis
L Romero‐Pinel, S Martínez‐Yélamos… - European journal of …, 2010 - Wiley Online Library
Background and objective: Anticipation of age at onset in the younger generations is a
widely known characteristic of many diseases with genetic inheritance. This study was …
widely known characteristic of many diseases with genetic inheritance. This study was …
Does narcolepsy symptom severity vary according to HLA-DQB1* 0602 allele status?
NF Watson, TGN Ton, TD Koepsell, VH Gersuk… - Sleep, 2010 - academic.oup.com
Abstract Study Objectives: To investigate associations between HLA-DQB1* 0602 allele
status and measures of narcolepsy symptom severity. Design: Cross-sectional study of …
status and measures of narcolepsy symptom severity. Design: Cross-sectional study of …
Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia
We aimed to characterize the clinical profile and human leukocyte antigen (HLA)-DRB1
genotype of patients with late onset multiple sclerosis (LOMS) in Western Australia. The …
genotype of patients with late onset multiple sclerosis (LOMS) in Western Australia. The …
Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study
Background: Previous studies on the influence of HLA-DRB1 alleles on multiple sclerosis
(MS) susceptibility and clinical course have mostly employed the 2-point genotyping …
(MS) susceptibility and clinical course have mostly employed the 2-point genotyping …
HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia
Susceptibility to multiple sclerosis (MS) has been consistently associated with the Human
Leukocyte Antigen (HLA)-DRB1⁎ 1501 genotype, however effects on disease severity and …
Leukocyte Antigen (HLA)-DRB1⁎ 1501 genotype, however effects on disease severity and …