Cannabinoids act via cell surface G protein-coupled receptors (CB1 and CB2) and the ion
channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is …

Obesity‐induced inflammation contributes to the development of obesity‐related metabolic
disorders such as insulin resistance, type 2 diabetes, fatty liver disease, and cardiovascular …

Little is known about the role of the transcription factor peroxisome proliferator-activated
receptor (PPAR) β/δ in liver. Here we set out to better elucidate the function of PPARβ/δ in …

Chronic inflammation is an important factor contributing to human carcinoma, and non-
steroidal anti-inflammatory drugs (NSAIDs) have been shown to have a preventive effect in …

Overweight and obesity are associated with low grade of inflammation and chronic
inflammatory response characterized by abnormal production and activation of some pro …

Fetal intrauterine growth restriction (IUGR) is a frequently occurring and serious
complication of pregnancy. Infants exposed to IUGR are at risk for numerous perinatal …

Brain-derived neurotropic factor (BDNF) mediates many aspects of neuronal function, and
plays a chief role in the central regulation of energy balance. In the periphery, it is expressed …

Obesity has been associated with increased incidence and aggressiveness of prostate
cancer. Although controversial, several studies suggest that leptin could influence tumour …

The shared physiopathologic derangements linking nonalcoholic fatty liver disease (NAFLD)
with the metabolic syndrome (MetS), along with the biological basis of treatment, will be …

Methyl 2-cyano-3, 11-dioxo-18-olean-1, 12-dien-30-oate (CDODA-Me), a triterpenoid acid
derived synthetically from glycyrrhetinic acid, has been characterized as a peroxisome …