Adjuvants enhance immunity to vaccines and experimental antigens by a variety of
mechanisms. In the past decade, many receptors and signaling pathways in the innate …

The effective vaccines developed against a variety of infectious agents, including polio,
measles, and hepatitis B, represent major achievements in medicine. These vaccines …

Polyinosinic: polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in
vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We …

T cells encounter their cognate antigens in specialized compartments of secondary
lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T …

Experiments performed in mice revealed that anthracyclines stimulate immunogenic cell
death that is characterized by the pre-apoptotic exposure of calreticulin (CRT) on the surface …

Found in translation: the human equivalent of mouse CD8+ dendritic cells - PMC Back to Top
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The mouse lymphoid organ-resident CD8α+ dendritic cell (DC) subset is specialized in Ag
presentation to CD8+ T cells. Recent evidence shows that mouse nonlymphoid tissue …

Dendritic cells (DCs) are professional antigen‐presenting cells (APCs) that are critical for the
generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and …

Understanding dendritic cell (DC) subset functions should lead to the development of novel
types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) …

Elevated amounts of glutamate, which acts as a neurotransmitter but is also a neurotoxin,
are a hallmark of the autoimmune neurological disease multiple sclerosis and may …