Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
H Quach, D Ritchie, AK Stewart, P Neeson, S Harrison… - Leukemia, 2010 - nature.com
Immunomodulatory drugs (IMiDs) are thalidomide analogues, which possess pleiotropic anti-
myeloma properties including immune-modulation, anti-angiogenic, anti-inflammatory and …
myeloma properties including immune-modulation, anti-angiogenic, anti-inflammatory and …
Regulatory T cells and breast cancer: implications for immunopathogenesis
MAE Watanabe, JMM Oda, MK Amarante… - Cancer and Metastasis …, 2010 - Springer
Current understanding of the role of several cancer risk factors is more comprehensive, as
reported for a number of sites, including the brain, colon, breasts, and ovaries. Despite such …
reported for a number of sites, including the brain, colon, breasts, and ovaries. Despite such …
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody
DM Benson Jr, CE Bakan, A Mishra… - Blood, The Journal …, 2010 - ashpublications.org
T-cell expression of programmed death receptor-1 (PD-1) down-regulates the immune
response against malignancy by interacting with cognate ligands (eg, PD-L1) on tumor cells; …
response against malignancy by interacting with cognate ligands (eg, PD-L1) on tumor cells; …
Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA‐DR−/low Myeloid‐Derived Suppressor Cells and Decreased Level of Dendritic Cells in …
MK Brimnes, AJ Vangsted, LM Knudsen… - Scandinavian …, 2010 - Wiley Online Library
Patients with multiple myeloma (MM) suffer from a general impaired immunity comprising
deficiencies in humoral responses, T‐cell responses as well as dendritic cell (DC) function …
deficiencies in humoral responses, T‐cell responses as well as dendritic cell (DC) function …
[HTML][HTML] Indoleamine 2, 3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells
A Curti, S Trabanelli, C Onofri, M Aluigi… - …, 2010 - ncbi.nlm.nih.gov
Background The immunoregulatory enzyme indoleamine 2, 3-dioxygenase, which catalyzes
the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients …
the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients …
Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44+) and T (HLA-DR+) cells
M Lioznov, J El-Cheikh, F Hoffmann… - Bone marrow …, 2010 - nature.com
We investigated efficacy and toxicity of lenalidomide in 24 heavily pretreated myeloma
patients with a median age of 59 years (range: 37–70) and relapse after allo-SCT …
patients with a median age of 59 years (range: 37–70) and relapse after allo-SCT …
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
Regulatory T cells (Tregs) are required for the maintenance of immune homeostasis as first
clearly described by Herman Waldmann's laboratory. Dysfunction of Treg cells also leads to …
clearly described by Herman Waldmann's laboratory. Dysfunction of Treg cells also leads to …
Reduced immune effector cell NKG2D expression and increased levels of soluble NKG2D ligands in multiple myeloma may not be causally linked
M von Lilienfeld-Toal, S Frank, C Leyendecker… - Cancer immunology …, 2010 - Springer
Background There is limited understanding of the dysregulation of the innate immune
system in multiple myeloma (MM). We analysed the expression of the activating receptor …
system in multiple myeloma (MM). We analysed the expression of the activating receptor …
[PDF][PDF] CD4 (+) CD25 (+) Foxp3 (+) regulatory T cells and hematologic malignancies
TW Kelley, CJ Parker - Front Biosci (Schol Ed), 2010 - article.imrpress.com
Introduction 3. Regulatory T cells in non-hematopoietic disorders 4. Regulatory T cells in
lymphoma ' 4.1 Follicular lymphoma 4.2 Hodgkin lymphoma. 4.3 Diffuse large B cell …
lymphoma ' 4.1 Follicular lymphoma 4.2 Hodgkin lymphoma. 4.3 Diffuse large B cell …
[HTML][HTML] Regulatory function of cytomegalovirus-specific CD4+ CD27− CD28− T cells
A Tovar-Salazar, J Patterson-Bartlett, R Jesser… - Virology, 2010 - Elsevier
CMV infection is characterized by high of frequencies of CD27− CD28− T cells. Here we
demonstrate that CMV-specific CD4+ CD27− CD28− cells are regulatory T cells (TR). CD4+ …
demonstrate that CMV-specific CD4+ CD27− CD28− cells are regulatory T cells (TR). CD4+ …