Genetic instability is one of the principal hallmarks and causative factors in cancer. Human
transposable elements (TE) have been reported to cause human diseases, including …

Transposable elements can be viewed as natural DNA transfer vehicles that, similar to
integrating viruses, are capable of efficient genomic insertion. The mobility of class II …

Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty
(SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result …

Efficient integration of functional genes is an essential prerequisite for successful gene
delivery such as cell transfection, animal transgenesis, and gene therapy. Gene delivery …

RNA interference (RNAi) is a powerful strategy for studying the phenotypic consequences of
reduced gene expression levels in model systems. To develop a method for the rapid …

Background Transposons are useful molecular tools for transgenesis. The'sleeping
beauty'transposon is a synthetic member of the Tc1/mariner transposon family. Davidson et …

Transposons have been effectively utilized as non-viral gene delivery systems that are
capable of promoting stable transgene expression in mammalian and human cells. Two …

Transposable elements (TEs) have been used to study the genetics of a wide variety of
species, including prokaryotes, plants, yeast, and Drosophila. The use of TEs to study …

Transposons (transposable elements, TEs) are DNA fragments capable of transposition, ie,
changing their location in the genome. They can spread inside single genomes, between …

RNA interference (RNAi) is a powerful strategy for studying the phenotypic consequences of
reduced gene expression levels in model systems. To develop a method for the rapid …