The process of megakaryopoiesis and platelet production is complex, with the potential for
regulation at multiple stages. Megakaryocytes are derived from the hematopoietic stem cell …

The aim of this study was to examine the induction of oxidative stress and apoptosis-
associated gene expression profiles in retina after proton irradiation exposure at 0.5 to 4 Gy …

Signal transducer and activator of transcription-5 (STAT5) is a critical transcription factor for
normal hematopoiesis and its sustained activation is associated with hematologic …

Background Pituitary corticotroph tumors secrete excess adrenocorticotrophic hormone
(ACTH) resulting in Cushing's disease (CD). Standard treatment includes surgery and, if not …

Background Grb2-associated binding (Gab) adapter proteins play major roles in
coordinating signaling downstream of hematopoietic cytokine receptors. In hematopoietic …

In a previous study, we underlined the functional role of the TPO receptor, Mpl, in the
establishment of definitive mouse hematopoiesis, by demonstrating that the lack of Mpl led …

Background: The pro-apoptotic BH3-only protein Bim is recognized as a pivotal regulator of
apoptosis induced by the depletion of cytokines. In the present study, we examined the role …

Symmetry is a defining feature of floral diversity. Here we review the evolutionary and
ecological context of floral symmetry (adding new data regarding its distribution), as well as …