Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD …

The calcium ion (Ca2+) plays fundamental roles in orchestrating dynamic changes in the
function and structure of nerve cell circuits in the brain. The endoplasmic reticulum (ER), an …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder.
Familial AD (FAD) mutations in presenilins have been linked to calcium (Ca2+) signaling …

Alzheimer's disease (AD) a progressive neurodegenerative disorder of later life, is
characterized by brain deposition of amyloid β-protein (Aβ) plaques, accumulation of …

β-Secretase (BACE1), an enzyme responsible for the production of amyloid β-peptide (Aβ),
is increased by oxidative stress and is elevated in the brains of patients with sporadic …

Abstract Mutations in presenilin-1 (PS1) and presenilin-2 (PS2) cause familial Alzheimer's
disease (FAD). Presenilins influence multiple molecular pathways and are best known for …

Increased oxidative stress is a widely accepted factor in the development and progression of
Alzheimer's disease. Here we introduced alginate–an antioxidant oligosaccharide–as a …

According to the prevailing “amyloid cascade hypothesis,” genetic dementias such as
Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits …

Introduction• Dysregulation of Ca2+ homeostasis in AD‐Aβ accumulation causes Ca2+
dyshomeostasis‐Ca2+ dyshomeostasis increases Aβ production• Presenilins and Ca2+ …

Amyloid beta (Aβ) peptides derived from proteolytic cleavage of amyloid precursor protein
(APP) are thought to be a pivotal toxic species in the pathogenesis of Alzheimer's disease …