Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
P Nicholson, H Yepiskoposyan, S Metze… - Cellular and molecular …, 2010 - Springer
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance
mechanism that ensures the speedy degradation of mRNAs containing premature …
mechanism that ensures the speedy degradation of mRNAs containing premature …
NMD: RNA biology meets human genetic medicine
M Bhuvanagiri, AM Schlitter, MW Hentze… - Biochemical …, 2010 - portlandpress.com
NMD (nonsense-mediated mRNA decay) belongs to the best-studied mRNA surveillance
systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the …
systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the …
[HTML][HTML] The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila
D Ashton-Beaucage, CM Udell, H Lavoie, C Baril… - Cell, 2010 - cell.com
Signaling pathways are controlled by a vast array of posttranslational mechanisms. By
contrast, little is known regarding the mechanisms that regulate the expression of their core …
contrast, little is known regarding the mechanisms that regulate the expression of their core …
[HTML][HTML] Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene
JY Roignant, JE Treisman - Cell, 2010 - cell.com
The exon junction complex (EJC) is assembled on spliced mRNAs upstream of exon-exon
junctions and can regulate their subsequent translation, localization, or degradation. We …
junctions and can regulate their subsequent translation, localization, or degradation. We …
[HTML][HTML] Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance
Planarian regeneration depends on the presence and precise regulation of pluripotent adult
somatic stem cells named neoblasts, which differentiate to replace cells of any missing …
somatic stem cells named neoblasts, which differentiate to replace cells of any missing …
Characteristics of transposable element exonization within human and mouse
Insertion of transposed elements within mammalian genes is thought to be an important
contributor to mammalian evolution and speciation. Insertion of transposed elements into …
contributor to mammalian evolution and speciation. Insertion of transposed elements into …
Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13
Mago and Y14 are core components of the exon junction complex (EJC), an assembly
central to nonsense-mediated mRNA decay in humans and mRNA localization in flies. The …
central to nonsense-mediated mRNA decay in humans and mRNA localization in flies. The …