The two faces of hepatitis E virus

JM Hughes, ME Wilson, EH Teshale… - Clinical infectious …, 2010 - academic.oup.com
Hepatitis E virus (HEV) has at least 2 distinct epidemiological profiles:(1) large outbreaks
and epidemics in developing countries, usually caused by HEV genotype 1, resulting in high …

Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial

FC Zhu, J Zhang, XF Zhang, C Zhou, ZZ Wang… - The Lancet, 2010 - thelancet.com
Background Seroprevalence data suggest that a third of the world's population has been
infected with the hepatitis E virus. Our aim was to assess efficacy and safety of a …

[HTML][HTML] Much meat, much malady: changing perceptions of the epidemiology of hepatitis E

CG Teo - Clinical Microbiology and Infection, 2010 - Elsevier
Hepatitis E, which is caused by hepatitis E virus (HEV), may now be considered a zoonosis
as well as an anthroponosis. Pigs, boars and deer have been identified as reservoirs, and …

Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection

N Kamar, L Rostaing, F Abravanel, C Garrouste… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Hepatitis E virus (HEV) infection can evolve to chronic hepatitis in
immunocompromised patients. Pegylated α-interferon can effectively treat chronic HEV …

Pegylated interferon-α for treating chronic hepatitis E virus infection after liver transplantation

N Kamar, L Rostaing, F Abravanel… - Clinical Infectious …, 2010 - academic.oup.com
This study assessed the effect of a 3-month course of pegylated interferon-α-2a (Peg-IFN-α-
2a) in 3 liver transplant patients with chronic active hepatitis E. A virological response was …

Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France

F Legrand-Abravanel, N Kamar… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Hepatitis E virus (HEV) infections can lead to chronic hepatitis in
immunocompromised patients. We have investigated the risk factors for HEV infection …

Brief communication: case reports of ribavirin treatment for chronic hepatitis E

V Mallet, E Nicand, P Sultanik… - Annals of internal …, 2010 - acpjournals.org
Background: There is currently no accepted treatment of chronic hepatitis E virus (HEV)
infection. Objective: To report 2 patients in whom ribavirin therapy seemed to alter the …

[HTML][HTML] Hepatitis E virus‐induced neurological symptoms in a kidney‐transplant patient with chronic hepatitis

N Kamar, J Izopet, P Cintas, C Garrouste… - American Journal of …, 2010 - Elsevier
It has been shown that hepatitis E virus (HEV) may be responsible for chronic hepatitis in
solid‐organ transplant patients. It has also been suggested that HEV may be responsible for …

Three-month pegylated interferon-alpha-2a therapy for chronic hepatitis E virus infection in a haemodialysis patient

N Kamar, F Abravanel, C Garrouste… - Nephrology Dialysis …, 2010 - academic.oup.com
Hepatitis E virus (HEV) can induce chronic hepatitis in immunosuppressed patients. There is
no established treatment for HEV infection. Pegylated interferon-alpha-2a (Peg-IFN-α-2a) …

Chronic hepatitis E virus infection: successful virologic response to pegylated interferon-α therapy

L Alric, D Bonnet, G Laurent, N Kamar… - Annals of internal …, 2010 - acpjournals.org
Background: Acute hepatitis E virus (HEV) infection is usually followed by complete
recovery, but some cases of chronic HEV infection have been reported. Objective: To report …