Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a
key component in numerous physiologic and pathologic responses and has broad impact in …

Abstract MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular
system. Recent studies have revealed that its expression is deregulated in heart and …

Purpose: Stem-like tumor cells comprise a highly tumorigenic and therapy-resistant tumor
subpopulation, which is believed to substantially influence tumor initiation and therapy …

The metalloproteinases (MMPs, matrixins) are zinc-containing endopeptidases involved in
the metabolism of extracellular matrix as well as in the cleavage of other proteins. The MMP …

TM601 is a synthetic form of chlorotoxin, a 36-amino acid peptide derived from the venom of
the Israeli scorpion, Leirius quinquestriatus, initially found to specifically bind and inhibit the …

Emodin, aloe-emodin and rhein are major compounds in rhubarb (Rheum palmatum L.),
used in Chinese herbal medicine, and found to have antitumor properties including cell …

Tumor development is a complex process that relies on interaction and communication
between a number of cellular compartments. Much of the mass of a solid tumor is comprised …

The incidence and mortality of oral cancer in Taiwan have been increased during the last
decade, which could be mainly resulted from the difficulty in treatment related to metastasis …

Numerous difficulties are associated with the conduct of preclinical studies related to skin
and wound repair. Use of small animal models such as rodents is not optimal because of …

BACKGROUND AND PURPOSE Interleukin (IL)‐1β‐induced matrix metalloproteinase
(MMP‐9) expression is regulated by mitogen activated protein kinases (MAPKs) and NF‐κB …