Telomeres are the DNA–protein complexes that protect the ends of eukaryotic
chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding …

Aging is a multifactorial process where deterioration of body functions is driven by stochastic
damage while counteracted by distinct genetically encoded repair systems. To better …

CD28 costimulatory signal transduction in T lymphocytes is essential for optimal telomerase
activity, stabilization of cytokine mRNAs, and glucose metabolism. During aging and chronic …

Importance of the field: Vaccination is universally considered as the most effective tool for
the prevention of influenza, which represents a significant burden, both from a health-care …

Seropositivity for CMV is one of the parameters of the “immune risk profile” associated with
mortality in longitudinal studies of the very elderly and may accelerate immunosenescence …

We have evaluated the serum response to seasonal influenza vaccination in subjects of
different ages and associated this with the specific B cell response to the vaccine in vitro …

Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or
older and concurrently studied young subjects individually matched to each old subject for …

As a result of age-associated thymic atrophy, T cell production declines with age. Some
studies suggest that production undergoes an exponential decline starting at birth, while …

Background Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent
herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are …

For decades, the search for new vaccine adjuvants has been largely empirical. A series of
new adjuvants and related formulations are now emerging that are acting through identified …