Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Huntingtin proteolysis has been implicated in the molecular pathogenesis of Huntington
disease (HD). Despite an intense effort, the identity of the pathogenic smallest N-terminal …

Huntington's disease (HD) is a monogenic neurodegenerative disease characterized by
abnormal motor movements, personality changes and early death. In contrast to other …

Huntington's disease (HD) is a late-onset neurodegenerative disorder that is characterized
neuropathologically by the presence of neuropil aggregates and nuclear inclusions …

The type 1 cannabinoid receptor (CB1) is a crucial modulator of synaptic transmission in the
brain. Animal and postmortem human data suggest that mutant huntingtin represses CB1 …

Abstract Evaluation of transcriptional changes in the striatum may be an effective approach
to understanding the natural history of changes in expression contributing to the …

Huntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a
CAG repeat in the HD gene. Degeneration concentrating in the basal ganglia has been …

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and spinocerebellar ataxias …

Mitochondrial dysfunction is a central feature of a number of acute and chronic
neurodegenerative conditions, but clinically approved therapeutic interventions are only just …