Discovery of prostate cancer biomarkers by microarray gene expression profiling

KD Sørensen, TF Ørntoft - Expert review of molecular diagnostics, 2010 - Taylor & Francis
Prostate cancer is the most commonly diagnosed malignancy in males in the Western world.
This review focuses on advances in biomarker discovery for prostate cancer by microarray …

Innovative biomarkers for prostate cancer early diagnosis and progression

J You, P Cozzi, B Walsh, M Willcox, J Kearsley… - Critical reviews in …, 2010 - Elsevier
The marker currently used for prostate cancer (CaP) detection is an increase in serum
prostate-specific antigen (PSA). However, the PSA test which may give false positive or …

LNCaP Atlas: Gene expression associated with in vivoprogression to castration-recurrent prostate cancer

TL Romanuik, G Wang, O Morozova, A Delaney… - BMC medical …, 2010 - Springer
Background There is no cure for castration-recurrent prostate cancer (CRPC) and the
mechanisms underlying this stage of the disease are unknown. Methods We analyzed the …

PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression

D Gkika, M Flourakis, L Lemonnier, N Prevarskaya - Oncogene, 2010 - nature.com
Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …

Estrogen regulation of TRPM8 expression in breast cancer cells

D Chodon, A Guilbert, I Dhennin-Duthille, M Gautier… - BMC cancer, 2010 - Springer
Background The calcium-permeable cation channel TRPM8 (melastatin-related transient
receptor potential member 8) is over-expressed in several cancers. The present study aimed …

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms

PA Culp, D Choi, Y Zhang, J Yin, P Seto… - Clinical Cancer …, 2010 - AACR
Purpose: Targeted therapeutics have significantly changed the outcome for patients
diagnosed with cancer. Still, effective therapeutic intervention does not exist for many …

Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma

M Kamal, AM Shaaban, L Zhang, C Walker… - Breast cancer research …, 2010 - Springer
CUB and SUSHI multiple domain protein 1 (CSMD1) is a candidate tumour suppressor gene
that maps to chromosome 8p23, a region deleted in many tumour types including 50% of …

Androgen regulated TRPM8 expression: a potential mRNA marker for metastatic prostate cancer detection in body fluids

VU Bai, S Murthy, K Chinnakannu… - International …, 2010 - spandidos-publications.com
Identification of sensitive and specific biomarkers for early detection and prognosis of
prostate cancer is essential for timely and appropriate treatment of the disease in individual …

TRP channels in human prostate

C Van Haute, D De Ridder… - The Scientific World …, 2010 - Wiley Online Library
This review gives an overview of morphological and functional characteristics in the human
prostate. It will focus on the current knowledge about transient receptor potential (TRP) …

Gene based prediction of clinically localized prostate cancer progression after radical prostatectomy

D Talantov, TA Jatkoe, M Boehm, Y Zhang… - The Journal of …, 2010 - Elsevier
PURPOSE: Accurate estimates of recurrence risk are needed for optimal treatment of
patients with clinically localized prostate cancer. We combined an established nomogram …