Altered function of endogenous pain modulation has been proposed as a mechanism that
may underlie chronic pain conditions. Descending modulation of pain can be examined by …

The determination of how disordered sleep affects musculoskeletal pain, fatigue, mood, and
behavior is important in the assessment and management of patients with rheumatic illness …

STUDY OBJECTIVES: To assess the efficacy of cognitive-behavioral therapy for insomnia
(CBT-I) in patients with non-malignant chronic pain. METHODS: Twenty-eight subjects with …

BACKGROUND: Restless legs syndrome (RLS) is a medical condition with established
neuropathology and genetic associations. Significant questions have, however, recently …

The experiment investigated the impact of sleep restriction on pain perception and related
evoked potential correlates (laser-evoked potentials, LEPs). Ten healthy subjects with good …

Objectives Sleep disturbances and increased negative mood are common among chronic
pain patients. Research suggests that sleep disruption can contribute to increased pain; …

An increasing number of prospective studies suggest a bi-directional association between
the pain and sleep quality. Few of these investigations have controlled for synchronous …

Objective. To determine the effects of sodium oxybate (SXB) on sleep physiology and
sleep/wake-related symptoms in patients with fibromyalgia syndrome (FM). Methods. Of 304 …

OBJECTIVE: Patients with painful conditions often suffer from sleep disturbances. However,
changes in sleep pattern per se could also influence pain tolerance. Untreated obstructive …

Despite the extensive effort over several decades searching for new pharmacological tools
for clinical pain treatment, opioid analgesics remain the mainstay of contemporary pain …