Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway
The cap'n'collar (CNC) bZIP transcription factor Nrf2 controls expression of genes for
antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters …
antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters …
[HTML][HTML] Acetylation of tau inhibits its degradation and contributes to tauopathy
SW Min, SH Cho, Y Zhou, S Schroeder, V Haroutunian… - Neuron, 2010 - cell.com
Neurodegenerative tauopathies characterized by hyperphosphorylated tau include
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and …
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and …
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor
EM Bowers, G Yan, C Mukherjee, A Orry, L Wang… - Chemistry & biology, 2010 - cell.com
The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …
many gene regulatory pathways and protein acetylation events. Although p300 inhibitors …
Tuning acetylation levels with HAT activators: therapeutic strategy in neurodegenerative diseases
Neurodegenerative diseases, such as polyglutamine-related diseases, amyotrophic lateral
sclerosis, and Alzheimer's disease are accompanied by transcriptional dysfunctions, leading …
sclerosis, and Alzheimer's disease are accompanied by transcriptional dysfunctions, leading …
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy
LC Cerchietti, K Hatzi, E Caldas-Lopes… - The Journal of …, 2010 - Am Soc Clin Investig
B cell lymphoma 6 (BCL6), which encodes a transcriptional repressor, is a critical oncogene
in diffuse large B cell lymphomas (DLBCLs). Although a retro-inverted BCL6 peptide …
in diffuse large B cell lymphomas (DLBCLs). Although a retro-inverted BCL6 peptide …
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation
It remains uncertain how the DNA sequence of mammalian genes influences the
transcriptional response to extracellular signals. Here, we show that the number of CREB …
transcriptional response to extracellular signals. Here, we show that the number of CREB …
Function of a transcription factor CDX2 beyond its trophectoderm lineage specification
T Sakurai, H Bai, T Konno, A Ideta, Y Aoyagi… - …, 2010 - academic.oup.com
The transcription factor caudal-related homeobox 2 (CDX2) regulates trophectoderm
differentiation, but its function beyond trophectoderm differentiation is not well characterized …
differentiation, but its function beyond trophectoderm differentiation is not well characterized …
Kinetic mechanism of the Rtt109− Vps75 histone acetyltransferase− chaperone complex
BN Albaugh, EM Kolonko, JM Denu - Biochemistry, 2010 - ACS Publications
Rtt109 is a histone acetyltransferase (HAT) involved in promoting genomic stability, DNA
repair, and transcriptional regulation. Rtt109 associates with the NAP1 family histone …
repair, and transcriptional regulation. Rtt109 associates with the NAP1 family histone …
Histone chaperones, histone acetylation, and the fluidity of the chromogenome
The “chromogenome” is defined as the structural and functional status of the genome at any
given moment within a eukaryotic cell. This article focuses on recently uncovered …
given moment within a eukaryotic cell. This article focuses on recently uncovered …
Spectrum of CREBBP mutations in Indian patients with Rubinstein-Taybi syndrome
Abstract Rubinstein-Taybi syndrome (RSTS), a developmental disorder comprising
abnormalities that include mental retardation, an unusual facial appearance, broad thumbs …
abnormalities that include mental retardation, an unusual facial appearance, broad thumbs …