A major of Na+ absorptive process in the proximal part of intestine and kidney is
electroneutral exchange of Na+ and H+ by Na+/H+ exchanger type 3 (NHE3). During the …

BACKGROUND & AIMS: Trichohepatoenteric syndrome (THES) is an autosomal-recessive
disorder characterized by life-threatening diarrhea in infancy, immunodeficiency, liver …

The colon is believed to absorb NaCl via the coupled operation of apical Na/H exchanger-3
(NHE3) and Cl/HCO3 exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 …

Astroviruses are known to be a leading cause of diarrhea in infants and the
immunocompromised; however, our understanding of this endemic pathogen is limited …

Sodium/hydrogen exchangers (NHEs) play a major role in Na+ absorption, cell volume
regulation, and intracellular pH regulation. Of the nine identified mammalian NHEs, three …

The intestinal epithelium is dynamic, with proliferation of undifferentiated crypt cells
balanced by terminal differentiation and cell death at the colon surface or small intestinal …

Abstract Background Carbonic anhydrases (CAs) are a family of enzymes that regulate pH
homeostasis in various tissues. CA IX is an exceptional member of this family because in …

Humans can be considered as super-organisms with an internal ecosystem of diverse
symbiotic microbiota that have interactive metabolic processes. The homeostatic balance …

The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed
membrane protein that regulates intracellular pH. In the myocardium, NHE1 has been …

BROERE, N., M. CHEN, A. CINAR, AK SINGH, J. HILLESHEIM, B. RIEDERER, M.
LUNNEMANN, I. ROTTINGHAUS, A. KRABBENHÖFT, R. ENGELHARDT, B. RAUSCH, EJ …