mTOR signaling and drug development in cancer
J Dancey - Nature reviews Clinical oncology, 2010 - nature.com
Mammalian target of rapamycin (mTOR) is a protein kinase of the PI3K/Akt signaling
pathway. Activation of mTOR in response to growth, nutrient and energy signals leads to an …
pathway. Activation of mTOR in response to growth, nutrient and energy signals leads to an …
Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements
S Kummar, HX Chen, J Wright, S Holbeck… - Nature reviews Drug …, 2010 - nature.com
The rapid development of new therapeutic agents that target specific molecular pathways
involved in tumour cell proliferation provides an unprecedented opportunity to achieve a …
involved in tumour cell proliferation provides an unprecedented opportunity to achieve a …
Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors
BACKGROUND: A phase 3 trial demonstrated superiority at interim analysis for everolimus
over placebo in patients with metastatic renal cell carcinoma (mRCC) progressing on …
over placebo in patients with metastatic renal cell carcinoma (mRCC) progressing on …
Updates of mTOR inhibitors
H Zhou, Y Luo, S Huang - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation,
metabolism and angiogenesis. mTOR signaling is often dysregulated in various human …
metabolism and angiogenesis. mTOR signaling is often dysregulated in various human …
A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma
PB Johnston, DJ Inwards, JP Colgan… - American journal of …, 2010 - Wiley Online Library
Everolimus is an oral antineoplastic agent that targets the raptor mammalian target of
rapamycin (mTORC1). The phosphatidylinositol 3‐kinase/mTOR signal transduction …
rapamycin (mTORC1). The phosphatidylinositol 3‐kinase/mTOR signal transduction …
Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy
AB Stillebroer, PFA Mulders, OC Boerman, WJG Oyen… - European urology, 2010 - Elsevier
CONTEXT: The clinical management of patients with renal cell carcinoma (RCC) remains
difficult, and the development of new diagnostic, prognostic, and therapeutic tools is still …
difficult, and the development of new diagnostic, prognostic, and therapeutic tools is still …
Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma
DA White, P Camus, M Endo, B Escudier… - American journal of …, 2010 - atsjournals.org
Rationale: Noninfectious pneumonitis is a known class effect of mammalian target of
rapamycin (mTOR) inhibitors. Objectives: To assess the incidence, radiographic patterns …
rapamycin (mTOR) inhibitors. Objectives: To assess the incidence, radiographic patterns …
The mTOR pathway: a new target in cancer therapy
L Ciuffreda, C Di Sanza, UC Incani… - Current cancer drug …, 2010 - ingentaconnect.com
Mammalian target of rapamycin (mTOR) is a key protein kinase controlling signal
transduction from various growth factors and upstream proteins to the level of mRNA …
transduction from various growth factors and upstream proteins to the level of mRNA …
[HTML][HTML] Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway
CB Ching, DE Hansel - Laboratory investigation, 2010 - Elsevier
A complex equilibrium of biological signals exists within the human body to regulate normal
cellular function and growth. Unfortunately, there are various ways in which disruption of …
cellular function and growth. Unfortunately, there are various ways in which disruption of …
Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis
PF McAuliffe, F Meric-Bernstam, GB Mills… - Clinical breast …, 2010 - Elsevier
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression …
(mTOR) pathway mediates multiple cellular functions critical to tumor initiation, progression …