Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin
resistance and diabetes-related morbidity and mortality. Population-based studies show that …

Experimental, epidemiological and clinical evidence implicates insulin resistance and its
accompanying hyperinsulinaemia in the development of cancer, but the relative importance …

Polycystic ovary syndrome (PCOS) is a common fertility disorder with metabolic sequelae.
Our lab previously characterized reproductive phenotypes in a prenatally androgenized …

Exercise is a robust physiological stimulator of the pituitary secretion of growth hormone
(GH), and within approximately 15 min after the onset of exercise, plasma GH starts to …

Background and objectives: A cutoff of 155 mg/dl for 1-hour postload plasma glucose
(1hPG) during the oral glucose tolerance test (OGTT) is able to identify patients who are at …

Context Chronic starvation is characterized by GH resistance, and obesity is characterized
by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels …

OBJECTIVE There is a complex relationship between IGF-I, IGF binding proteins, growth
hormone, and insulin. The IGF-I kinase receptor activation assay (KIRA) is a novel method …

Context Control of disease activity in acromegaly is critical, but the biochemical definitions
remain controversial. Objective To compare traditional and novel biomarkers and health …

Objective Clinical response to GH therapy in GH-deficient (GHD) adults varies widely. Good
predictors of treatment response are lacking. The aim of the study was to develop …

BACKGROUND Menstrual disturbances in female athletes are often explained as a
consequence of energy deficiency. Oral contraceptive (OC) treatment may have favorable …