LIBBY P et al. the procoagulant tissue factor (TF). 2–5 Examples of specific mediators
involved in initiation of atherosclerotic plaques include vascular cell adhesion molecule-1 …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to
human health worldwide. Despite important progress in prevention and treatment, these …

Wnt signaling has been implicated in certain inflammatory diseases. However, the biological
role in the inflammatory regulation remains to be characterized. We investigated the …

Murine atherosclerosis models are highly valuable for identifying atherogenic mechanisms
that can be targeted by preventive medicine. However, models with thrombotic …

Rationale: Transient receptor potential melastatin (TRPM) 3 is a calcium-permeable ion
channel activated by the neurosteroid pregnenolone sulfate and positively coupled to insulin …

Biliary cholesterol secretion is a process important for 2 major disease complexes,
atherosclerotic cardiovascular disease and cholesterol gallstone disease. With respect to …

The endothelium is an essential component of the cardiovascular system, playing a vital role
in blood vessel formation, vascular homeostasis, permeability and the regulation of …

Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated
forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial …

Atherosclerosis is linked to inflammation. HDL protects against atherosclerotic
cardiovascular disease, mainly by mediating cholesterol efflux and reverse cholesterol …