In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern
biological research. This process, which involves the noninvasive interrogation of living …

Bioluminescent imaging (BLI) is a non‐invasive imaging modality widely used in the field of
pre‐clinical oncology research. Imaging of small animal tumour models using BLI involves …

Despite the high doses of radiation delivered in the treatment of patients with glioblastoma
multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low …

Recent advances in radiotherapy technology now enable us to deliver a booster dose of
radiation to small target fractions in a malignant tumor. To fully exploit this technology in …

In recent years, molecular imaging gained significant importance in biomedical research.
Optical imaging developed into a modality which enables the visualization and …

Hypoxia-inducible factor (HIF) functions as a master transcriptional regulator for adaptation
to hypoxia by inducing adaptive changes in gene expression for regulation of proliferation …

Importance of the field: Cancer is both a major health concern and a care-cost issue in the
US and the rest of the world. It is estimated that there will be a total of 1,479,350 new cancer …

Survival and growth of cellular grafts in tissue engineering (TE) are limited by the rate of
oxygen (O2) and nutrient diffusion. As such, monitoring the levels of nutrients and O2 …

Abstract Purpose Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant
tumour progression. For the imaging of HIF-1-active tumours, we previously developed a …

One of the first reports describing the use of recombinant aequorin as a reporter molecule in
a bioluminometric nucleic acid hybridization assay was in 1996.1 Microtiter wells were …