There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

Aurora kinase family of serine/threonine kinases are important regulators of mitosis that are
frequently over expressed in human cancers and have been implicated in oncogenic …

RalA expression in human prostate cancer is associated with cell migration and is
necessary for bone metastasis. However, the downstream effectors of RalA that mediate …

Our recent studies established essential and distinct roles for RalA and RalB small GTPase
activation in K-Ras mutant pancreatic ductal adenocarcinoma (PDAC) cell line …

RalA and RalB are monomeric G proteins that are 83% identical in amino acid sequence but
have paralogue-specific effects on cell proliferation, metastasis, and apoptosis. Using in vitro …

Up to one-third of human melanomas are characterized by an oncogenic mutation in the
gene encoding the small guanosine triphosphatase (GTPase) NRAS. Ras proteins activate …

Wrch-1 is an atypical Rho family small GTPase with roles in migration, epithelial cell
morphogenesis, osteoclastogenesis, and oncogenic transformation. Here, we observed …

Summary RLIP76 (RalBP1) is a multidomain protein that interacts with multiple small G
protein families: Ral via a specific binding domain, and Rho and R-Ras via a GTPase …

Aurora-A kinase is frequently overexpressed/activated in various types of human
malignancy, including prostate cancer. In this study, we demonstrate elevated levels of …