A number of drugs have been withdrawn from the market or severely restricted in their use
because of unexpected toxicities that become apparent only after the launch of new drug …

The US Food and Drug Administration (FDA), concerned about the incidence of acute liver
failure due to acetaminophen (Tylenol) overdose, has mandated new labeling on …

Genetic polymorphisms in xenobiotic metabolizing enzymes can have profound influence on
enzyme function, with implications for chemical clearance and internal dose. The effects of …

El acetaminofén es uno de los analgésicos de más amplio uso en el mundo. Su buen perfil
de seguridad, eficacia y el hecho de ser de un medicamento de venta libre, hacen que la …

Importance of the field: The field of drug-induced liver injury (DILI) continues to expand in
terms of global registries and with new agents added every year. Given the need to improve …

Background: Intravenous N-acetylcysteine (IV-NAC) is widely recognized as the antidote of
choice for acetaminophen overdose. However, its use is not without adverse drug reactions …

Imatinib, a selective tyrosine kinase inhibitor, is the first line treatment against chronic
myelogenous leukaemia (CML) and gastrointestinal stromal tumors (GIST). Several fatal …

We evaluated whether repeated arsenic preexposure can increase acetaminophen-induced
hepatic oxidative stress. Rats were exposed to arsenic (25ppm; rat equivalent concentration …

U ovom preglednom članku opisani su svi do sada poznati mehanizmi toksičnog dejstva
paracetamola na jetru. U terapijskim dozama paracetamol je vrlo efikasan antipiretik i …

Paracetamol overdose (POD) is a major cause of acute liver failure (ALF) requiring liver
transplantation in the United Kingdom. To characterize the early and late outcome after …