This Timeline article looks back at 40 years of research into the inherited genetic basis of
cancer and the insights these studies have yielded. Early epidemiological research provided …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence bound by a
specialized six‐protein complex known as shelterin, which has fundamental roles in the …

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected
individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies …

Context Telomeres are essential to preserve the integrity of the genome. Critically short
telomeres lead to replicative cell senescence and chromosomal instability and may thereby …

We conducted a multi-stage, genome-wide association study of bladder cancer with a
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …

We conducted a genome-wide association study for testicular germ cell tumor, genotyping
298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating …

We performed a genome-wide association study on 1,292 individuals with abdominal aortic
aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up …

Previously, we reported germline DNA variants associated with risk of urinary bladder
cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set …

It is now 5 years since the first genome-wide association studies (GWAS), published in 2005,
identified a common risk allele with large effect size for age-related macular degeneration in …

Genome-wide association studies of lung cancer reported in populations of European
background have identified three regions on chromosomes 5p15. 33, 6p21. 33, and 15q25 …