Although commonly related to nutrient deprivation, the cause of the formation of the necrotic
core in the multicellular tumour spheroids is still a controversial issue. We propose a simple …

This thesis considers aspects of modelling solid tumours. We begin by considering the
common assumption that nutrient or drug concentrations in avascular tumour spheroids are …

The work presented in this thesis is concerned with modelling the growth of tissue
constructs, with particular focus on the effects the local micro environment has on the cell …