Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial
obstruction increases pulmonary vascular resistance, which leads to right ventricular (RV) …

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease characterized
by a persistent elevation of pulmonary artery pressure accompanied by right ventricular …

The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …

Translational research on endogenous gaseous mediators—nitric oxide, carbon monoxide,
and hydrogen sulfide—has exploded over the past decade. Drugs that modulate either the …

Hospitalization for heart failure (HF) marks a substantial crossroad for patients, as greater
than one-third will be re-hospitalized or dead within 90 days post-discharge. For patients …

Objectives The nitric oxide–soluble guanylate cyclase (sGC)–cGMP signal transduction
pathway is impaired in different cardiovascular diseases, including pulmonary hypertension …

Heme is a vital molecule for all life forms with heme being capable of assisting in catalysis,
binding ligands, and undergoing redox changes. Heme-related dysfunction can lead to …

The endothelium plays a crucial role in the control of vascular homoeostasis through
maintaining the synthesis of the vasoprotective molecule NO•(nitric oxide). Endothelial …

Pulmonary hypertension (PH) encompasses a group of diseases associated with
progressively increasing pulmonary vascular resistance, right heart failure and premature …

Background and purpose: Soluble guanylate cyclase (sGC) is the signal transduction
enzyme most responsible for mediating the effects of nitric oxide (NO). Recently, NO …