The beating heart requires a constant flux of ATP to maintain contractile function, and there
is increasing evidence that energetic defects contribute to the development of heart failure …

Lifestyle-related diseases are rapidly increasing at least in part due to less physical activity.
The health beneficial effects of regular physical activity include metabolic adaptations in …

Background Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs
of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human …

Skeletal muscle contraction increases intracellular ATP turnover, calcium flux, and
mechanical stress, initiating signal transduction pathways that modulate peroxisome …

Long chain fatty acids and pharmacologic ligands for the peroxisome proliferator activated
receptor alpha (PPARα) activate expression of genes involved in fatty acid and glucose …

Aims Impairment in mitochondrial energetics is a common observation in animal models of
heart failure, the underlying mechanisms of which remain incompletely understood. It was …

Mammals possess an intricate regulatory system for controlling flux through fuel utilization
pathways in response to the dietary availability of particular macronutrients. Under fasting …

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-
CoA in mitochondria and is a key regulatory enzyme in the oxidation of glucose to acetyl …

Members of the sirtuin family of NAD+-dependent protein deacetylases are important
regulators of longevity in yeast, worms, and flies. Mammals have seven sirtuins (SIRT1-7) …

Background—Emerging evidence in obesity and diabetes mellitus demonstrates that
excessive myocardial fatty acid uptake and oxidation contribute to cardiac dysfunction …