Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility
DB Warren, H Benameur, CJH Porter… - Journal of drug …, 2010 - Taylor & Francis
The inclusion of certain polymers within solid dispersion or lipid-based formulations can
maintain drug supersaturation after dispersion and/or digestion of the vehicle, leading to …
maintain drug supersaturation after dispersion and/or digestion of the vehicle, leading to …
Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory− Huggins interaction parameter and phase …
K Pajula, M Taskinen, VP Lehto… - Molecular …, 2010 - ACS Publications
The Flory− Huggins interaction parameter has been shown to be useful in predicting the
thermodynamic miscibility of a polymer and a small molecule in a binary mixture. In the …
thermodynamic miscibility of a polymer and a small molecule in a binary mixture. In the …
Role of polymer chemistry in influencing crystal growth rates from amorphous felodipine
The inhibition of crystallization from organic amorphous solids is currently of great interest in
the pharmaceutical field, since the amorphous form of the drug can enhance drug delivery …
the pharmaceutical field, since the amorphous form of the drug can enhance drug delivery …
An improved kinetics approach to describe the physical stability of amorphous solid dispersions
J Yang, K Grey, J Doney - International journal of pharmaceutics, 2010 - Elsevier
The recrystallization of amorphous solid dispersions may lead to a loss in the dissolution
rate, and consequently reduce bioavailability. The purpose of this work is to understand …
rate, and consequently reduce bioavailability. The purpose of this work is to understand …