Abstract Steroidogenic factor 1 (SF-1)-expressing neurons of the ventromedial
hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells …

The control of energy homeostasis within the hypothalamus is under the regulated control of
homeostatic hormones, nutrients and the expression of neuropeptides that alter feeding …

Lipotoxicity involves pathological alterations to cells and tissues in response to elevated fat
levels in blood. Furthermore, this process can disturb both cellular homeostasis and viability …

Evidence shows that neuropeptide Y (NPY) neurons are involved in mediating the
anorexigenic action of leptin via neuronal circuits in the hypothalamus. However, studies …

Obesity and diabetes have been shown to be associated with cognitive impairment or early
neurodegeneration. However, the cellular mechanisms that link between these two …

Aims/hypothesis Lon protease degrades oxidatively damaged proteins in mitochondrial
matrix. To examine the relationships between mitochondrial quality control, mitochondrial …

Background Translational control is utilized as a means of regulating gene expression in
many species. In most cases, posttranscriptional regulatory mechanisms play an important …

A new study used several mouse mutants to study insulin receptor function specifically in the
ventromedial nucleus of the hypothalamus (VMH), and found a role for VMH insulin …

This study investigated the effects and possible targets of Fructus Broussonetiae extract, a
traditional Chinese medicinal herb, on a model of Alzheimer's disease induced by beta …

Growing evidence from the last decades intimately links obesity with insulin resistance and
type 2 diabetes mellitus as a consequence. Thus, the role of the central nervous system and …