Sepsis-related organ dysfunction remains the most common cause of death in the intensive
care unit (ICU), despite advances in healthcare and science. Marked oxidative stress as a …

The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and
septic shock have been the subject of investigations for nearly half a century. Controversies …

Sepsis with secondary multisystem organ dysfunction syndrome is the leading cause of
death in the pediatric intensive care unit. Increased reactive oxygen species may influence …

Animal studies as well as prospective randomized clinical trials associated sepsis with redox
imbalance and oxidative stress, but other studies failed to establish a correlation between …

Introduction Mitochondrial dysfunction is associated with increased mortality in septic shock.
Coenzyme Q10 (CoQ10) is a key cofactor in the mitochondrial respiratory chain, but whether …

Background Trauma is the number one killer of individuals 1–44 y of age in the United
States. The prognosis and treatment of inflammatory complications in critically injured …

The pathogenesis of sepsis-induced acute kidney injury (AKI) is not fully understood, and
may involve altered systemic hemodynamics and renal circulation, renal hypoxia and …

Introduction Multiple organ dysfunction is the main cause of death in severe acute
pancreatitis. Primary mitochondrial dysfunction plays a central role in the development and …

Oxidative stress and mitochondrial dysfunction are common features in patients with sepsis
and organ failure. Within mitochondria, superoxide is converted into hydrogen peroxide by …

Oxidative stress is a term relative to the elevated levels of reactive free radicals in an
organism. Oxidative stress can occur from diminished antioxidants and/or increased …