IgG FcRs are important mediators of immunity and play a key role during Ab-based
immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable of IgG …

Peptide–protein interactions are among the most prevalent and important interactions in the
cell, but a large fraction of those interactions lack detailed structural characterization. The …

Background Macromolecular complexes are the molecular machines of the cell. Knowledge
at the atomic level is essential to understand and influence their function. However, their …

The amyloid fibrils of beta-amyloid (Aβ) peptides play important roles in the pathology of
Alzheimer's disease. Comprehensive solid-state NMR (SSNMR) structural studies on …

Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2,
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator …

Prediction of protein-protein interactions at the structural level on the proteome scale is
important because it allows prediction of protein function, helps drug discovery and takes …

The vast majority of the chores in the living cell involve protein–protein interactions.
Providing details of protein interactions at the residue level and incorporating them into …

Background Traditional antibiotics are increasingly suffering from the emergence of
multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to …

Amyloids are β-sheet-rich proteinaceous aggregates that are a pathological hallmark of a
number of human diseases.[1] They can replicate by seeded nucleation and propagate as …

Clustered regularly interspaced short palindromic repeats (CRISPRs) and Cas proteins
represent an adaptive microbial immunity system against viruses and plasmids. Cas3 …