Systems-biology approaches for predicting genomic evolution
Is evolution predictable at the molecular level? The ambitious goal to answer this question
requires an understanding of the mutational effects that govern the complex relationship …
requires an understanding of the mutational effects that govern the complex relationship …
Elimination of thermodynamically infeasible loops in steady-state metabolic models
The constraint-based reconstruction and analysis (COBRA) framework has been widely
used to study steady-state flux solutions in genome-scale metabolic networks. One …
used to study steady-state flux solutions in genome-scale metabolic networks. One …
Optimization of a blueprint for in vitro glycolysis by metabolic real-time analysis
M Bujara, M Schümperli, R Pellaux… - Nature chemical …, 2011 - nature.com
Recruiting complex metabolic reaction networks for chemical synthesis has attracted
considerable attention but frequently requires optimization of network composition and …
considerable attention but frequently requires optimization of network composition and …
Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development
E Katz, KH Boo, HY Kim, RA Eigenheer… - Journal of …, 2011 - academic.oup.com
Abstract Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the
differential protein synthesis and metabolite profiling in order to assess metabolic changes …
differential protein synthesis and metabolite profiling in order to assess metabolic changes …
An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data
AB Canelas, C Ras, A ten Pierick, WM van Gulik… - Metabolic …, 2011 - Elsevier
Kinetic modeling of metabolism holds great potential for metabolic engineering but is
hindered by the gap between model complexity and availability of in vivo data. There is also …
hindered by the gap between model complexity and availability of in vivo data. There is also …
Mathematical models of cell factories: moving towards the core of industrial biotechnology
Industrial biotechnology involves the utilization of cell factories for the production of fuels
and chemicals. Traditionally, the development of highly productive microbial strains has …
and chemicals. Traditionally, the development of highly productive microbial strains has …
A practical guide to genome-scale metabolic models and their analysis
Genome-scale metabolic reconstructions and their analysis with constraint-based modeling
techniques have gained enormous momentum. It is a natural next step after sequencing of a …
techniques have gained enormous momentum. It is a natural next step after sequencing of a …
A database of thermodynamic properties of the reactions of glycolysis, the tricarboxylic acid cycle, and the pentose phosphate pathway
A database of thermodynamic properties is developed, which extends a previous database
of glycolysis and tricarboxylic acid cycle by adding the reactions of the pentose phosphate …
of glycolysis and tricarboxylic acid cycle by adding the reactions of the pentose phosphate …
Connecting genotype to phenotype in the era of high-throughput sequencing
BACKGROUND: The development of next generation sequencing technology is rapidly
changing the face of the genome annotation and analysis field. One of the primary uses for …
changing the face of the genome annotation and analysis field. One of the primary uses for …
Noninvasive measurement and identification of biomarkers in disease state
FM Assadi-Porter, ME Cook, HR Eghbalnia… - US Patent …, 2011 - Google Patents
The invention is methods and related kits for diagnosing a disease state of cachexia by
measuring biomarker profiles from a biological sample. Rapid measurement of early onset …
measuring biomarker profiles from a biological sample. Rapid measurement of early onset …