Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
HB Clay, S Sillivan, C Konradi - International Journal of Developmental …, 2011 - Elsevier
Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …
The 22q11. 2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders
LJ Drew, GW Crabtree, S Markx, KL Stark… - International Journal of …, 2011 - Elsevier
Over the last fifteen years it has become established that 22q11. 2 deletion syndrome
(22q11DS) is a true genetic risk factor for schizophrenia. Carriers of deletions in …
(22q11DS) is a true genetic risk factor for schizophrenia. Carriers of deletions in …
Exome sequencing supports a de novo mutational paradigm for schizophrenia
Despite its high heritability, a large fraction of individuals with schizophrenia do not have a
family history of the disease (sporadic cases). Here we examined the possibility that rare de …
family history of the disease (sporadic cases). Here we examined the possibility that rare de …
Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex
Individuals with 22q11. 2 microdeletions have cognitive and behavioral impairments and the
highest known genetic risk for developing schizophrenia. One gene disrupted by the 22q11 …
highest known genetic risk for developing schizophrenia. One gene disrupted by the 22q11 …
Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
MR Bennett - Progress in neurobiology, 2011 - Elsevier
Gray matter loss in the cortex is extensive in schizophrenia, especially in the prefrontal-
temporal-network (PTN). Several molecules such as neuregulin-1 (NRG1) and its ErbB4 …
temporal-network (PTN). Several molecules such as neuregulin-1 (NRG1) and its ErbB4 …
[HTML][HTML] Using the R package crlmm for genotyping and copy number estimation
Genotyping platforms such as Affymetrix can be used to assess genotype-phenotype as well
as copy number-phenotype associations at millions of markers. While genotyping algorithms …
as copy number-phenotype associations at millions of markers. While genotyping algorithms …
[HTML][HTML] Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex
CM Schofield, R Hsu, AJ Barker, CC Gertz… - Neural …, 2011 - Springer
Background Neuronal phenotypes associated with hemizygosity of individual genes within
the 22q11. 2 deletion syndrome locus hold potential towards understanding the …
the 22q11. 2 deletion syndrome locus hold potential towards understanding the …
Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome
CL Clelland, LL Read, AN Baraldi, CP Bart… - Schizophrenia …, 2011 - Elsevier
There are multiple genetic links between schizophrenia and a deficit of proline
dehydrogenase (PRODH) enzyme activity. However, reports testing for an association of …
dehydrogenase (PRODH) enzyme activity. However, reports testing for an association of …
[HTML][HTML] Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia
N Takashima, YS Odaka, K Sakoori, T Akagi… - PLoS …, 2011 - journals.plos.org
Recent genetic linkage analysis has shown that LRRTM1 (Leucine rich repeat
transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized …
transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized …
The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
J Larimore, K Tornieri, PV Ryder… - Molecular biology of …, 2011 - Am Soc Cell Biol
Dysbindin assembles into the biogenesis of lysosome-related organelles complex 1 (BLOC-
1), which interacts with the adaptor protein complex 3 (AP-3), mediating a common …
1), which interacts with the adaptor protein complex 3 (AP-3), mediating a common …