The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Building and maintaining a homeostatic relationship between a host and its colonizing
microbiota entails ongoing complex interactions between the host and the microorganisms …

Bacteria and fungi can form a range of physical associations that depend on various modes
of molecular communication for their development and functioning. These bacterial-fungal …

Antimicrobial peptides (AMPs) are ribosomally synthesized natural antibiotics that are
crucial effectors of innate immune systems in all living organisms. AMPs are diverse …

The development of new antibacterial agents to combat worsening antibiotic resistance is
still a priority area in anti-infectives research, but in the post-genomic era it has been more …

Antimicrobial peptides are present in all walks of life, from plants to animals, and they are
considered to be endogenous antibiotics. In general, antimicrobial peptides are …

This review summarizes ongoing research aimed at finding novel drugs as alternatives to
traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies …

Since the discovery of magainins, cecropins and defensins 30 years ago, antimicrobial
peptides (AMPs) have been hailed as a potential solution to the dearth of novel antibiotic …

Defensins are small basic amphiphilic peptides (up to 5 kDa) that have been shown to be
important effector molecules of the innate immune system of animals, plants and fungi. In …

Paneth cells at the base of small intestinal crypts of Lieberkühn secrete high levels of α-
defensins in response to cholinergic and microbial stimuli. Paneth cell α-defensins are …