Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety
of developmental and adult processes in all metazoan organisms. Recent advances in the …

The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as
associated organs. To generate a functional intestine, a series of highly orchestrated …

Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer
(TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack …

Wnt morphogens control embryonic development and homeostasis in adult tissues. In
vertebrates the N-terminal WIF domain (WIF-1WD) of Wnt inhibitory factor 1 (WIF-1) binds …

Wnt/β-catenin signaling is known for its role in embryogenesis as well as carcinogenesis. In
the liver, it plays many critical roles during hepatic development and regeneration, and its …

The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic
stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate …

The Wnt pathway inhibitors DKK1 and sclerostin (SOST) are important therapeutic targets in
diseases involving bone loss or damage. It has been appreciated that Wnt coreceptors …

Gradient formation and signaling ranges of secreted proteins are crucial problems to
understand how morphogens work for positional information and patterning in animal …

The Wnt/β‐catenin pathway is an evolutionarily conserved signaling cascade that plays key
roles in development and adult tissue homeostasis and is aberrantly activated in many …

In addition to its role in cellular development and proliferation, there are emerging in vitro
data implicating the Wnt/β-catenin pathway in synaptic plasticity. Yet in vivo studies have not …