Physiologically-based pharmacokinetics in drug development and regulatory science
M Rowland, C Peck, G Tucker - Annual review of pharmacology …, 2011 - annualreviews.org
The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of
age in drug development and regulation, reflecting significant advances over the past 10 …
age in drug development and regulation, reflecting significant advances over the past 10 …
An evaluation of using population pharmacokinetic models to estimate pharmacodynamic parameters for propofol and bispectral index in children
MJ Coppens, DJ Eleveld, JH Proost… - The Journal of the …, 2011 - pubs.asahq.org
Background To study propofol pharmacodynamics in a clinical setting a pharmacokinetic
model must be used to predict drug plasma concentrations. Some investigators use a …
model must be used to predict drug plasma concentrations. Some investigators use a …
Essential drugs in anesthetic practice
FS Servin, JW Sear - cambridge.org
Intravenous anesthetics are used primarily for induction of general anesthesia, and some
are also used for maintenance of anesthesia or for sedation. The ideal characteristics are a …
are also used for maintenance of anesthesia or for sedation. The ideal characteristics are a …
Nonrespiratory functions of the lung
L Yeazell, K Littlewood - Principles and Practice of Anesthesia for Thoracic …, 2011 - Springer
Pulmonary endothelial cells metabolize endogenous substances and xenobiotics via ecto-
enzymes on their luminal surface and caveolae or enzyme systems within their cytosol …
enzymes on their luminal surface and caveolae or enzyme systems within their cytosol …
Studio della farmacocinetica del Propofol, progettazione e validazione di un sistema di target controlled infusion nel gatto
T Pilla - 2011 - research.unipd.it
Il Propofol, 2, 6-di-isopropylfenolo (PPF) è un farmaco anestetico rapidamente
metabolizzato, con caratteristiche ipnotiche e sedative. Viene somministrato, nei piccoli …
metabolizzato, con caratteristiche ipnotiche e sedative. Viene somministrato, nei piccoli …
Intravenous Infusions for Sedation: Rationale, State of the Art, and Future Trends
AR Absalom - Pediatric Sedation Outside of the Operating Room: A …, 2011 - Springer
Intravenous Infusions for Sedation: Rationale, State of the Art, and Future Trends |
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[PDF][PDF] Early Phase Pharmacokinetics of Propofol in Humans: the Role of the Lung Explored by Recirculatory Modeling
M Reekers, F Boer, E Olofsen… - … in Man using …, 2011 - scholarlypublications …
The pharmacology of the induction of anesthesia is still poorly understood and often roughly
described using compartmental modeling. The inability to describe and predict the plasma …
described using compartmental modeling. The inability to describe and predict the plasma …