Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

Y Xu - Chemical Society Reviews, 2011 - pubs.rsc.org
Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an
important role in critical processes underlying genome stability, cancer, and aging, and their …

Quadruplex DNA: a promising drug target for the medicinal inorganic chemist

SF Ralph - Current Topics in Medicinal Chemistry, 2011 - ingentaconnect.com
Compounds that can bind to and stabilize quadruplex DNA structures in telomeres, or
induce formation of such structures from ssDNA, represent an attractive general approach to …

Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G‐Quadruplex Formation under Salt‐Deficient Conditions

C Zhao, J Geng, L Feng, J Ren… - Chemistry–A European …, 2011 - Wiley Online Library
Chiral molecular recognition of human telomeric DNA is important for rational drug design
and developing structural probes of G‐quadruplexes. Here we report that a chiral …

Solution‐Stable Triple Helicates of Quaterimidazole: Three‐Dimensional Crystal Structures and Optical Resolution by Chiral‐Column HPLC

Y Yakiyama, T Murata, T Ise, D Shiomi, K Sato, T Takui… - 2011 - Wiley Online Library
Complex formation of quaterimidazole with FeII, CoII, and NiII yielded dinuclear triple
helicates in the solution state by the self‐assembling ability of the ligand based on the strong …

[PDF][PDF] Interaction of Metal Complexes with G‐Quadruplexes

O Jarjayes, T Lavergne, F Thomas - Encyclopedia of Inorganic and …, 2011 - hal.science
Guanine rich sequences were identified in distinct locations within the genome, and
proposed to be ubiquitous in the human genome. They confer to DNA the ability to fold …

[PDF][PDF] Discrete supramolecular metal complexes: Synthesis, structures, host-guest chemistry with anions, and DNA binding properties

A Galstyan - 2011 - Citeseer
I wish to express my heartfelt gratitude to Dr. Pablo Sanz Miguel for his contribution in the
measurement and refinement of X-ray structures, without which, most of the results in this …