Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-
dependent oxidoreductase residing in the mitochondrial intermembrane space whose …

Leber's hereditary optic neuropathy, the most frequent mitochondrial disease due to
mitochondrial DNA point mutations in complex I, is characterized by the selective …

Eukaryotic cells harbor a small multiploid mitochondrial genome, organized in nucleoids
spread within the mitochondrial network. Maintenance and distribution of mitochondrial DNA …

The similarities between glaucoma and mitochondrial optic neuropathies have driven a
growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal …

Ionizing radiation is known to increase intracellular level of reactive oxygen species (ROS)
through mitochondrial dysfunction. Although it has been as a basis of radiation-induced …

Charcot–Marie–Tooth (CMT) disease represents a large group of clinically and genetically
heterogeneous disorders leading to inherited peripheral neuropathies affecting motor and …

This articles reviews the development of mitochondrial medicine from the premolecular era
(1962–1988), when mitochondrial diseases were defined on the basis of clinical …

In the last decade, there was the seminal discovery of melanopsin-expressing retinal
ganglion cells (mRGCs) as a new class of photoreceptors that subserve the …

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and
fusion events, forming networks. These dynamic events allow the transmission of chemical …