Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

It is well established that ATP-dependent chromatin remodelers modulate DNA access of
transcription factors and RNA polymerases by" opening" or" closing" chromatin structure …

Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore
conceivable that chromatin-borne information participates in alternative splicing. Here we …

There is increasing evidence to suggest that splicing decisions are largely made when the
nascent RNA is still associated with chromatin. Here we demonstrate that activity of histone …

PURPOSE:: Abnormal miRNA expression has emerged as crucial factors in carcinogenesis
and is important in the comprehension of prostate cancer behavior. We determined the …

Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and
heat shock (HS), with the synthesis of poly-[ADP-ribose](PAR) at specific chromatin regions …

Assembly of the spliceosome onto pre-mRNA is a dynamic process involving the ordered
exchange of snRNPs to form the catalytically active spliceosome. These ordered …

Splicing of RNA polymerase II transcripts is a crucial step in gene expression and a key
generator of mRNA diversity. Splicing and transcription have generally been studied in …

The conserved SWI/SNF chromatin remodeling complex uses the energy from ATP
hydrolysis to alter local chromatin environments through disrupting DNA-histone contacts …

Nucleocytoplasmic export and biogenesis of mRNPs are closely coupled. At the gene,
concomitant with synthesis of the pre-mRNA, the transcription machinery, hnRNP proteins …