Out of the several signaling pathways controlling craniofacial development, the role of
planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally …

The vertebrate Cdx genes (Cdx1, Cdx2 and Cdx4) encode homeodomain transcription
factors with well-established roles in anteroposterior patterning. To circumvent the peri …

Vertebrate mesendoderm specification requires the Nodal signaling pathway and its
transcriptional effector FoxH1. However, loss of FoxH1 in several species does not reliably …

Proteoglycans are molecules consisting of protein cores onto which sugar chains, ie,
glycosaminoglycans (GAGs) such as heparan or chondroitin sulphates, are attached …

Progression through the cell cycle relies on oscillation of cyclin-dependent kinase (Cdk)
activity. One mechanism for downregulating Cdk signaling is to activate opposing …

Leucine zipper tumor suppressor 2 (Lzts2) functions in the development and progression of
various tumors, but its activities in vertebrate embryogenesis remain unclear. Here, we …

The role of bone morphogenetic protein (BMP) signaling in specifying cell fate in the
zebrafish tailbud has been well established. In addition to a loss of ventral tissues, such as …

Shortly after fertilization the vertebrate embryo starts an intensive cycle of cell division that
often do not imply growth in size. This process originates a mass of cells known as …

The study of animal development is one of the oldest disciplines in the field of biology and
the collected data from countless investigations on numerous species have formed a …

The cellular and molecular mechanisms generating the diversity of animal morphologies are
still a relatively little explored subject within developmental biology. While changes in cell …