HIV treatment adherence, drug resistance, virologic failure: evolving concepts

JB Nachega, VC Marconi, GU van Zyl… - … Current Drug Targets …, 2011 - ingentaconnect.com
Poor adherence to combined antiretroviral therapy (cART) has been shown to be a major
determinant of virologic failure, emergence of drug resistant virus, disease progression …

Pharmacy adherence measures to assess adherence to antiretroviral therapy: review of the literature and implications for treatment monitoring

JH McMahon, MR Jordan, K Kelley… - Clinical Infectious …, 2011 - academic.oup.com
Prescription or pill-based methods for estimating adherence to antiretroviral therapy (ART),
pharmacy adherence measures (PAMs), are objective estimates calculated from routinely …

Optimizing adherence to antiretroviral therapy

S Sahay, KS Reddy, S Dhayarkar - Indian Journal of Medical …, 2011 - journals.lww.com
HIV has now become a manageable chronic disease. However, the treatment outcomes
may get hampered by suboptimal adherence to ART. Adherence optimization is a concrete …

Adherence to drug-refill is a useful early warning indicator of virologic and immunologic failure among HIV patients on first-line ART in South Africa

Z El-Khatib, D Katzenstein, G Marrone, F Laher… - PloS one, 2011 - journals.plos.org
Background Affordable strategies to prevent treatment failure on first-line regimens among
HIV patients are essential for the long-term success of antiretroviral therapy (ART) in sub …

Association between medication possession ratio, virologic failure and drug resistance in HIV-1–infected adults on antiretroviral therapy in Côte d'Ivoire

E Messou, ML Chaix, D Gabillard, A Minga… - JAIDS Journal of …, 2011 - journals.lww.com
Background: Adherence is a strong determinant of viral suppression with antiretroviral
therapy (ART) but measuring it is challenging. Medication delivery can be measured …

[HTML][HTML] Neuropsychiatric and socioeconomic status impact antiretroviral adherence and mortality in rural Zambia

GL Birbeck, MP Kvalsund, PA Byers… - The American journal …, 2011 - ncbi.nlm.nih.gov
We conducted a prospective cohort study of 496 adults starting antiretroviral treatment (ART)
to determine the impact of neuropsychiatric symptoms and socioeconomic status on …

Monitoring adherence to antiretroviral treatment in Brazil: an urgent challenge

GM Rocha, CJ Machado, FA Acurcio… - Cadernos de saude …, 2011 - SciELO Brasil
The aim of this study was to describe the effect of non-adherence on the main laboratory
outcomes, TCD4+ lymphocyte count and viral load, routinely used to monitor patients …

Validating five questions of antiretroviral nonadherence in a public-sector treatment program in rural South Africa

K Chaiyachati, LR Hirschhorn, F Tanser… - AIDS patient care and …, 2011 - liebertpub.com
Simple questions are the most commonly used measures of antiretroviral treatment (ART)
adherence in sub-Saharan Africa (SSA), but rarely validated. We administered five …

Development and validation of systems for rational use of viral load testing in adults receiving first-line ART in sub-Saharan Africa

M Abouyannis, J Menten, A Kiragga, L Lynen… - Aids, 2011 - journals.lww.com
Background: World Health Organization (WHO) immunological and clinical criteria for
monitoring first-line antiretroviral treatment (ART) offer low accuracy for predicting viral …

Monitoring Antiretroviral Therapy in HIV‐Infected Children in Resource‐Limited Countries: A Tale of Two Epidemics

E Paintsil - AIDS research and treatment, 2011 - Wiley Online Library
Twenty‐nine years into the HIV epidemic, several advances have been made; however,
there remain several challenges particularly with pediatric HIV in resource‐limited countries …