Clinical trials in cystic fibrosis (CF) patients established proof-of-principle for transfer of the
wild-type cystic fibrosis transmembrane conductance regulator (CFTR) gene to airway …

PLUNC (palate, lung and nasal epithelium clone)-associated gene originally referred to one
gene, but now has been extended to represent a gene family that consists of a number of …

In most HCO 3−-secreting epithelial tissues, SLC26 Cl−/HCO 3− transporters work in concert
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the …

Background H5N1 influenza vaccines, including live intranasal, appear to be relatively less
immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein …

To create a model system that investigates mechanisms resulting in hyperplasia and
hypertrophy of respiratory tract submucosal glands, we developed an in vitro three …

Background Cystic fibrosis (CF), caused by reduced CFTR function, includes severe
sinonasal disease which may predispose to lung disease. Newly developed CF pigs provide …

—We investigated how cystic fibrosis (CF) alters the relationship between Cl− and mucin
secretion in cultures of non-CF and CF human tracheobronchial gland mucous (HTGM and …

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR)
chloride channels causes defective secretion by submucosal glands (SMGs), leading to …

Autonomic neural control of the intrathoracic airways aids in optimizing air flow and gas
exchange. In addition, and perhaps more importantly, the autonomic nervous system …

Cystic Fibrosis (CF), the most common autosomal lethal disorder in Caucasians, is caused
by mutations in the CF transmembrane conductance regulator (CFTR) gene. Although CF is …