Mucosal surfaces are colonized by large communities of commensal bacteria and represent
the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B …

Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently
in B‐cell maturation and function. In particular, B‐cell activating factor belonging to the TNF …

Background Common variable immunodeficiency (CVID) is a heterogeneous immune defect
characterized by hypogammaglobulinemia, failure of specific antibody production …

Common variable immune deficiency (CVID) is the commonest symptomatic primary
immunodeficiency and represents a heterogenous collection of disorders resulting mostly in …

Primary immunodeficiencies (PIDs) are commonly characterized by an increased
susceptibility to specific infections and, in certain instances, a higher than usual incidence of …

Common variable immunodeficiency (CVID) is the most frequent clinically expressed
primary immunodeficiency in adults and is characterized by primary defective …

The prototypic autoimmune disease, SLE, is known to be associated with polyclonal B cell
hyperreactivity. Developing an understanding of the complex nature of human B cell …

Common variable immunodeficiency disorder (CVID) is the most prevalent form of primary
idiopathic hypogammaglobulinemia. Identification of genetic defects in CVID is hampered by …

Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class
switching and somatic hypermutation, two Ig gene-diversifying processes that usually …

Deficiencies in transmembrane activator and CAML interactor (TACI) result in common
variable immune deficiency, a syndrome marked by recurrent infections with encapsulated …