Nanoparticles escaping RES and endosome: challenges for siRNA delivery for cancer therapy
Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …
Polymers in small-interfering RNA delivery
This review will cover the current strategies that are being adopted to efficiently deliver small
interfering RNA using nonviral vectors, including the use of polymers such as …
interfering RNA using nonviral vectors, including the use of polymers such as …
Research progress on siRNA delivery with nonviral carriers
Y Gao, XL Liu, XR Li - International journal of nanomedicine, 2011 - Taylor & Francis
RNA interference is a powerful method for the knockdown of pathologically relevant genes.
Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical …
Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical …
Maltose-and maltotriose-modified, hyperbranched poly (ethylene imine) s (OM-PEIs): physicochemical and biological properties of DNA and siRNA complexes
S Höbel, A Loos, D Appelhans, S Schwarz… - Journal of controlled …, 2011 - Elsevier
Polycationic non-viral polymers are widely employed as delivery platforms of plasmid DNA,
or of small interfering RNAs (siRNAs) for the induction of RNA interference (RNAi). Among …
or of small interfering RNAs (siRNAs) for the induction of RNA interference (RNAi). Among …
Impact of lipid substitution on assembly and delivery of siRNA by cationic polymers
HM Aliabadi, B Landry, RK Bahadur… - Macromolecular …, 2011 - Wiley Online Library
Abstract Characterization of a polymer library engineered to enhance their ability to protect
and deliver their nucleotide cargo to the cells is reported. The ζ‐potential continuously …
and deliver their nucleotide cargo to the cells is reported. The ζ‐potential continuously …
Phospholipid–polyethylenimine conjugate-based micelle-like nanoparticles for siRNA delivery
G Navarro, RR Sawant, S Essex… - Drug Delivery and …, 2011 - Springer
Gene silencing using small interfering RNA (siRNA) is a promising therapeutic strategy for
the treatment of various diseases, in particular, cancer. Recently, our group reported on a …
the treatment of various diseases, in particular, cancer. Recently, our group reported on a …
Using drug-excipient interactions for siRNA delivery
K Bruno - Advanced drug delivery reviews, 2011 - Elsevier
SiRNA is the trigger of RNA interference, a mechanism discovered in the late 1990s. To
release the therapeutic potential of this versatile but large and fragile molecule, excipients …
release the therapeutic potential of this versatile but large and fragile molecule, excipients …
Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy
Several bacterial species have inherent ability to colonize solid tumors in vivo. However,
their natural anti-tumor activity can be enhanced by genetic engineering that enables these …
their natural anti-tumor activity can be enhanced by genetic engineering that enables these …
PEI-g-PEG-RGD/Small Interference RNA Polyplex-Mediated Silencing of Vascular Endothelial Growth Factor Receptor and Its Potential as an Anti-Angiogenic Tumor …
Tumor angiogenesis appears to be achieved by the expression of vascular endothelial
growth factor (VEGF) within solid tumors that stimulate host vascular endothelial cell …
growth factor (VEGF) within solid tumors that stimulate host vascular endothelial cell …
Drug carriers
Y Niitsu, L Yu, J Liu, G Zhao, N Ma, S Van - US Patent 8,003,621, 2011 - Google Patents
US8003621B2 - Drug carriers - Google Patents US8003621B2 - Drug carriers - Google Patents
Drug carriers Download PDF Info Publication number US8003621B2 US8003621B2 …
Drug carriers Download PDF Info Publication number US8003621B2 US8003621B2 …